Diagnosis

In this section you will be able to read more about the following:

Infections due to complement deficiencies - a general introduction 

One important function of complement is to protect the host from microbial infections.

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Assessment of complement deficiencies

Complement deficiencies predispose to an increased susceptibility to infection, in particular caused by Neisseria meningitidis, and to a minor extent by Streptococcus pneumonia and Haemophils influenza. It is therefore of utmost importance to assess the presence of these deficiencies, especially when the patient has experienced recurrent infections.

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Autoimmune disease monitoring - a general introduction

In autoimmune disease the immune system reacts against the molecules and cells of the organism itself. The immune reaction leads to inflammation which in turn may lead to organ damage.

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Autoimmune disease monitoring - how to use complement testing results

Analysis of complement in autoimmune disease is important for the diagnosis and monitoring particularly in SLE where increased activation of the classical pathway is a typical finding. Also in several other autoimmune diseases increased complement activation is seen.

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Complement in relation to unexplained angioedema and to hemolytic anemia – a general introduction

The complement system, when not properly regulated may be the cause to several different symptoms and diseases such as angioedema and anemia.

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Complement testing in angioedema and hemolytic anemia

In unexplained angioedema it is important to consider C1-inhibitor (C1-INH) deficiency. Deficiency of C1-INH deficiency can be genetically determined that is hereditary or acquired.

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aHUS

Atypical hemolytic uremic syndrome (aHUS) is a very rare, life-threatening disease of genetic origin. Although the symptoms are similar, the underlying mechanism in aHUS is distinctly different from typical HUS, also called STEC-HUS, which is caused by infection of shiga toxin producing E. coli. aHUS accounts for ca 10% of all HUS cases and clear-cut diagnosis to distinguish between the two types is of greatest importance.

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